Causes:

• Genetic factor like Down’s syndrome or Mongolism
• Birth injuries leading to cerebral palsy or poor APGAR score
• Infections affecting brain and its coverings like encephalitis, meningitis
• Prenatal infections in mother like cytomegalovirus, rubella, etc.
• Intake of alcohol, narcotics, cigarettes by mother during pregnancy
• Late pregnancy i.e maternal age more than 35
• Birth defects affecting the development of the child
• Metabolic disorders like hyperthyroidism, cretinism
• Exposure to certain toxins, radiations and chemicals like lead, mercury.
• Nutritional deficiencies like Iodine deficiency
• Head injuries.

Down Syndrome:
It is a genetic disorder in which instead of normal 46 chromosomes, one more additional chromosome is present. This defect occurs during cell division when genetic material exchange and rearrangement takes place and primarily affects the 21 st chromosome, hence Down’s syndrome is also known as 21 trisomy. The children suffering from this have a typical appearance. They usually have a short neck and small head, eyes which slant upwards and outwards, a single crease line on their palms, small hands and feet and poor muscle tone. Their growth is retarded, milestones delayed and their IQ is below normal. The children affected with Down may also have complications like congenital heart defects, gastrointestinal disorders like celiac disease, obesity, dementia.

Cerebral Palsy (CP):
It is a severe neurological disorder affecting the motor functioning of brain, thereby disrupting the ability to control posture, balance and movement of the body. The word cerebral palsy is derived from two terms “cerebral” meaning brain and “palsy” meaning weakness of muscles or muscular movement. Most common cause for CP is developmental defect or birth injury and usually affects the child from birth and their milestones are usually delayed. Often the children lack coordination in voluntary movements (ataxia), very stiff and tight muscles with heightened reflexes (spasticity) or very loose, floppy muscles with least resistance (hypo tonicity), and may have sudden random and uncontrolled movement of muscles(athetoid). Those who are able to walk show “scissored” gait or may walk on toes and have difficulty in precise movements like buttoning of the shirt. Many affected also suffer from tremors and weakness in arms and legs and difficult speech.